![]() Our results strongly suggest that orexin-A and opioid signaling in the BMA play a major role in regulating GD neuronal excitability and feeding behavior in obesity. In the DIO and DR rats, mRNA expression of OX-1R and μ-opioid receptors were increased in the BMA. Intra-BMA infusions of orexin-A increased the firing of BMA GD neurons and increased food intake, and that these effects could be abolished by pretreatment with the more » orexin-1 receptor (OX-1R) antagonist SB334867, these effects could also be somewhat attenuated by co-administration of naloxone. In the present experiment, we sought to ascertain the effects of orexin-A and μ-opioid signaling regulation in the basomedial amygdala (BMA) on feeding and investigate the physiology of gastric distension (GD)-responsive neurons in a diet-induced obesity (DIO) and diet-induced obesity resistance (DR) rat model. Orexin and opioid signaling can regulate feeding behavior and represent potential therapeutic targets for obesity. Obesity has become a global problem due to its sharply increased prevalence and associated complications. The NOP-compound-24 structure explains the divergent selectivity profile of NOP and provides a new structural template for the design of NOP ligands. 6), and these are probably due to a small number of residues that vary between these receptors. These example sentences are selected automatically from various online news sources to reflect current usage of the word 'insurmountable.' Views expressed in the examples do not represent the opinion of Merriam-Webster or its editors. 2022 But here’s the thing: Almost every last-minute note starts as an insurmountable wave of stress and ends in a solution that can exceed your original expectations for the project. Globe Staff,, 6 June 2022 Pollsters think the scale of that deficit, combined with the fact that the Tories will seek a record fifth term in office at the next election in 2024, is potentially insurmountable. 2022 The 35-14 Blitz by the Bay set the Celtics back an insurmountable amount (87-64), reanimated the Warriors, and reset the series. Theo Mackie, The Arizona Republic, 1 Oct. 2022 The 73 yards between Cowart’s team and the end zone felt almost insurmountable. 2022 After years of stocks climbing to profound heights and billionaires amassing insurmountable wealth, a bout of poor tech earnings has led to billions instantly slashed from the fortunes of company founders. The purpose of this study was to examine the inhibitory effects of AT-1015, a newly synthesized 5-HT(2) receptor antagonist, on serotonin-induced endothelium-dependent relaxation in U 46619 (5 x 10(-9)M)-precontracted porcine coronary artery pre-incubated with ketanserin (3 x 10(-6)M), and then compare its effects with another potent 5-HT(2) antagonist, ritanserin. 2022 Makoto, bullied into being a perfect student, only to ultimately crumble under insurmountable pressure. 2022 The deficit proved to be insurmountable for Cascade, who ultimately dropped the third game 25-16 as Marshfield won in straight sets (25-14, 25-23, 25-16) in front of a packed house at Springfield High School to claim the 4A championship. Michael Hiltzik, Los Angeles Times, 9 Nov. Recent Examples on the Web On Wednesday, however, Binance backed out of the deal, apparently having discovered an insurmountable financial hole in FTX’s books.
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